生长因子和细胞因子与血管内皮前体细胞在局部缺血后脑血管生成中的作用

生长因子和细胞因子与血管内皮前体细胞在局部缺血后脑血管生成中的作用

尽管科学界在脑卒中的治疗方面已取得很多进展，但针对替代疗法，即脑卒中治疗过程中如何将细胞疗法应用到临床治疗方面，我们仍然面对着许多挑战。某些生长因子在组织缺血的酸性条件和损害生物活性的因素下是较不稳定的，因此也了它们作为外源性介质的作用。来自新西兰奥塔哥大学的Philip V. Peplow博士认为生长因子类似物在低pH情况下是稳定的，并且可能会为脑卒中提供更好的治疗策略。目前研究者们已设计了一种合成基质细胞衍生多肽模拟因子，它们会更有效地诱导血管内皮祖细胞迁移，与体外使用的SDF- 1α进行比较，它们具有更好的稳定性和更强的功能。他汀类药物也已被广泛地应用于预防啮齿类动物脑卒中治疗中，并已被证明可以诱导血管内皮细胞生长因子、脑源性神经营养因子的表达进而促进内皮祖细胞（EPC）的活性与增殖。使用生长因子类似物或抑制剂/拮抗剂与他汀类药物和内皮祖细胞组合疗法为缺血性脑卒中开辟了新的修复治疗可能性。相关研究内容发表在2014年8月第15期《中国神经再生研究（英文版）》杂志上。

内皮祖细胞在脑缺血后的引导与功能性作用

Article: \"Growth factor- and cytokine-stimulated endothelial progenitor cells in post-ischemic cerebral neovascularization \" by Philip V. Peplow (Department of Anatomy, University of Otago, Dunedin, New Zealand)

Peplow PV. Growth factor- and cytokine-stimulated endothelial progenitor cells in post-ischemic cerebral neovascularization. Neural Regen Res. 2014;9(15):1425-1429.

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SICENCE新闻发布 作者：Philip V. Peplow 稿号：NRR-D-14-00110

Growth factor- and cytokine-stimulated endothelial progenitor cells in post-ischemic cerebral neovascularization

Growth factor- and cytokine-stimulated EPCs in post-ischemic cerebral neovascularization

Despite extensive research into stroke pathology, there remains several challenges facing the translation of cellular therapies for stroke from in vitro and animal studies to clinical trials. Some growth factors may be less stable under the acidic conditions of tissue ischemia and the biological activity of these factors impaired, thereby limiting their usefulness as exogenous mediators. Dr. Philip V. Peplow comes from University of Otago, New Zealand considered that growth factor analogues that are stable at low pH may provide a better therapeutic strategy. A synthetic SDF polypeptide analog has been engineered that is more effective in inducing endothelial progenitor cell (EPC) migration, including greater stability and function, compared with exogenous administered SDF-1α. Statins are widely used for preventing stroke and in rodents have been shown to induce the expression of VEGF and BDNF and promote mobilization and proliferation of EPCs. New possibilities for combinatorial therapies using administered growth factor analogues or inhibitors/antagonists, statins, and EPCs are opened up for the treatment of patients with ischemic stroke. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 15, 2014).

Homing and functional role of endothelial progenitor cells (EPCs) in post-cerebral ischemia

Article: \"Growth factor- and cytokine-stimulated endothelial progenitor cells in post-ischemic cerebral neovascularization \" by Philip V. Peplow (Department of Anatomy, University of Otago, Dunedin, New Zealand)

Peplow PV. Growth factor- and cytokine-stimulated endothelial progenitor cells in post-ischemic cerebral neovascularization. Neural Regen Res. 2014;9(15): 1425-1429.