Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :R406841290-81-1HY-12067628.63C28H29FN6O8S>98%Solubility:DMSO ≥124mg/mL Water<1.2mg/mL Ethanol ≥20mg/mLMechanisms: Pathways:Protein Tyrosine Kinase/RTK; Target:Syk gyBiological Activity:R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.References:[1]. Zhu Y et al. Immunotoxicity assessment for the novel Spleen tyrosine kinase inhibitor R406.Toxicol Appl Pharmacol. 2007 Jun 15;221(3):268-77. [2]. Lhermusier T, van Rottem J, Garcia C, Xuereb JM, Ragab A, Martin V, Gratacap MP, Sié P,Payrastre B.The Syk-kinase inhibitor R406 impairs platelet activation and monocyte tissue factoryyppyexpression triggered by heparin-PF4 complex directed antibodies.J Thromb Haemost. 2011Oct;9(10):2067-76. [3]. Sweeny DJ, Li W, Grossbard E, Lau DT.Contribution of gut bacteria to the metabolism of thespleen tyrosine kinase (Syk) inhibitor R406 in cynomolgus monkey.Xenobiotica. 2010 Jun;40(6):415-23. [4]. Sweeny DJ, Li W, Clough J, Bhamidipati S, Singh R, Park G, Baluom M, Grossbard E, LauDT.Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinaseinhibitor R406 in humans: contributio...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com 18 Wilkinson Way, Princeton, NJ 080,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com
