Resolution of 4,5-dimethoxy-1-(methylaminomenthyl)

专利名称：Resolution of 4,5-dimethoxy-1-(methylaminomenthyl)-benzocyclobutane

发明人：Piaoyang Sun,Yongjiang Chen,Guangliang Yu申请号：US12742632申请日：20081010公开号：US08198485B2公开日：20120612

摘要：A method of resolving an important chemical intermediate, 4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane, comprises the following steps: reacting its twoenantiomers of 4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane with di-p-toluoyl-L-tartaric acid (LDTTA) or di-p-toluoyl-D-tartaric acid (DDTTA) in an alcoholicsolution or an alcohol in water solution to give the corresponding salts, and thenresolving the salts. This method gives high enantiomer excess value, high yield which ismore than 80% in total with normal resolution and reverse resolution.

申请人：Piaoyang Sun,Yongjiang Chen,Guangliang Yu

地址：Jiangsu CN,Jiangsu CN,Jiangsu CN

国籍：CN,CN,CN

代理机构：Brinks Hofer Gilson & Lione

代理人：Ryan L. Marshall

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