Bicyclic triazole and pyrazole lactams as alloster

专利名称：Bicyclic triazole and pyrazole lactams as

allosteric modulators of mGluR5 receptors

发明人：P. Jeffrey Conn,Craig W. Lindsley,Shaun R.

Stauffer,José Manuel Bartolomé-Nebreda,Susana Conde-Ceide,Gregor JamesMacDonald,Han Min Tong,Carrie K.Jones,Manuel Jesús Alcázar-Vaca,JoséIgnacio Andrés-Gil,Chrysa Malosh

申请号：US13329025申请日：20111216公开号：US08592422B2公开日：20131126

摘要：In one aspect, the invention relates to bicyclic triazole and pyrazole lactams,derivatives thereof, and related compounds, which are useful as positive allostericmodulators of the metabotropic glutamate receptor subtype 5 (mGluR5); syntheticmethods for making the compounds; pharmaceutical compositions comprising thecompounds; and methods of treating neurological and psychiatric disorders associatedwith glutamate dysfunction using the compounds and compositions. This abstract isintended as a scanning tool for purposes of searching in the particular art and is notintended to be limiting of the present invention.

申请人：P. Jeffrey Conn,Craig W. Lindsley,Shaun R. Stauffer,José Manuel Bartolomé-Nebreda,Susana Conde-Ceide,Gregor James MacDonald,Han Min Tong,Carrie K.Jones,Manuel Jesús Alcázar-Vaca,José Ignacio Andrés-Gil,Chrysa Malosh

地址：Brentwood TN US,Brentwood TN US,Brentwood TN US,Toledo ES,ToledoES,Beerse BE,Toledo ES,Nashville TN US,Toledo ES,Toledo ES,Nashville TN US

国籍：US,US,US,ES,ES,BE,ES,US,ES,ES,US

代理机构：Ballard Spahr LLP

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