Preparation of biological material for implants

专利名称：Preparation of biological material for

implants

发明人：JOHN MICHAEL LEE申请号：AU1434097申请日：19970128公开号：AU1434097A公开日：19970822

摘要：A method for preparation of biological material for a medical device. Samplesof intact or acellular tissue of biological material are treated in vitro with (i) a water-soluble carbodiimide of the formula R1-N=C=N-R2, wherein R1 and R2 are independentlyselected from alkyl and alkylamino groups, in combination with (ii) an agent that forms astable activated ester with said carbodiimide. The agent to stabilize the activated esters ispreferably N-hydroxysuccinimide or N-hydroxysulfosuccinimide. The preferredcarbodiimide is 1-ethyl-3-(dimethylaminopropyl)-carbodiimide. The method reducesinflammatory reactions of xenografts.

申请人：JOHN MICHAEL LEE

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