Determination of Distribution

专利名称：Determination of Distribution发明人：Maria Lönnberg,Jan Carlsson申请号：US12999438申请日：20090527

公开号：US20110104822A1公开日：20110505

摘要：A method for determining the occurrence of an analyte subpopulation ofheteroforms of a substance (=S) in a liquid sample. The method comprises as its maincharacteristic features the step of: (i) providing a flow path which a) comprises an outletpart and an inlet part, b) comprises a capture zone (CZ) containing a solid phaseexhibiting an immobilized analyte specific binder (B) [=affinity counterpart to thesubstance] which is capable of affinity binding to S with an affinity that differs for thevarious heteroforms of S, and c) permits capillary suction from the outlet part for drivinga liquid flow through CZ, (ii) flowing said liquid sample containing S in the downstreamdirection through CZ while S is captured by said binder B in CZ, (iii) determining thedistribution of S along the flow direction in CZ by measuring the relative amount of S in atleast one subzonei of CZ, and (iv) determining the occurrence of the analytesubpopulation based on the distribution determined in step (iii).

申请人：Maria Lönnberg,Jan Carlsson

地址：Knivsta SE,Uppsala SE

国籍：SE,SE

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